IDENTIFICATION OF AFRICAN ELEPHANT POLYOMAVIRUS IN WILD ELEPHANTS AND THE CREATION OF A VECTOR EXPRESSING ITS VIRAL TUMOR ANTIGENS TO TRANSFORM ELEPHANT PRIMARY CELLS.

Identification of African Elephant Polyomavirus in wild elephants and the creation of a vector expressing its viral tumor antigens to transform elephant primary cells.

Wild elephant populations are declining rapidly due to rampant killing for ivory and body parts, range fragmentation, and human-elephant conflict.Wild and captive elephants are further impacted by viruses, including highly pathogenic elephant endotheliotropic herpesviruses.Moreover, while the rich genetic diversity of the ancient elephant lineage i

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Developmental Pathways Pervade Stem Cell Responses to Evolving Extracellular Matrices of 3D Bioprinted Microenvironments

Developmental studies and 3D in vitro model systems show that the production and engagement of extracellular matrix (ECM) often precede stem cell differentiation.Yet, unclear is how the ECM triggers signaling events in sequence to accommodate multistep process characteristic of differentiation.Here, we employ transcriptome profiling and advanced im

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